337543BR
Oct 04, 2022
USA

Job Description

Do you want to be at the forefront of the fight against multiple diseases making an impactful contribution in bringing transformative therapies to patients and be part of Novartis’ mission to reimagine medicine to improve and extend people’s lives?

PK Sciences (PKS) offers you this unique opportunity to make an impact where 450 projects are straddling discovery through development. PKS is a global organization of about 300 associates, within the Translational Medicine (TM) department, in Novartis Institutes of Biomedical Research (NIBR). It is an enterprise organization, unique to pharmaceutical industry, where you can work across both NIBR (Research) and the Global Drug Development (GDD) organizations to advance the scientific knowledge of pharmacokinetics, pharmacodynamics, metabolism and clinical pharmacology from discovery through approval and beyond. Novartis portfolio consists of projects in multiple therapeutic areas (Cardiovascular, Metabolic Diseases, Immunology, Hepatology, Dermatology, Oncology, Hematology, Neuroscience, Musculoskeletal Diseases, Respiratory, and Ophthalmology) using several therapeutic modalities including small molecules, biologics, gene therapy and cell therapy. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

In this role of Principal Scientist, you will collaborate with a cross-disciplinary team to select and characterize new chemical and biologic entities in research and development and implement clinical pharmacology strategies in early and late clinical development. You will represent the PK/PD/ADME discipline on discovery and development project teams, and suggest and implement strategies and tactics to advance high-quality entities as part of the overall program(s).

Major Accountabilities Include:
• The specific accountabilities of the role will be based on the stage of the program (preclinical or clinical)
• In this role you will provide matrix leadership to collaborate, align and influence across the cross-functional team to identify and mitigate key project issues related to the pharmacokinetic sciences discipline (PK, PK/PD, metabolism and clinical pharmacology).
• You will represent the PK/PD/ADME/Clinical Pharmacology discipline as per project need, and serve providing scientific expertise on global cross-functional project teams, leading the strategy, design, execution, and analysis of PKS preclinical and clinical studies.
• Working with subject matter experts in PKS and partner groups
• Support PKS components of preclinical and clinical study protocol designs, preclinical and clinical study reports, and investigator brochures, IND, NDA etc. Prepare for Health Authority calls/meetings/discussion and be responsible as PKS representative in these settings.
• Collaborate with other NIBR and GDD functions, bring innovative ideas and approaches, and a leadership, enterprise mindset that inform and influence the overall drug discovery and development process.
• Responsible for the compilation, seeking of approval and updating of Line Function specific elements of development plans to support the TPP (Target Product Profile).
• Evaluate in-licensing opportunities and carry out Due Diligence activities as required.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

Minimum requirements :
• PhD/PharmD in pharmacology/physiology, biochemistry, chemistry, pharmacokinetics/pharmaceutical sciences, or related sciences.
• Preferably 1-3 years of experience in pharmaceutical industry in a field related to PKS (e.g. Drug Metabolism and Pharmacokinetics).
• Familiarity with standard ADME/PK modelling tools such as Phoenix, GastroPlus, etc. is desirable
• Hands-on project experience with low molecular weight and biologics modalities desirable; and cell-based and/or gene-based therapies highly desirable.
• Proven record as team player/leader with superior communication skills.
• Demonstrated success working in a matrix environment.
• Excellent written and oral (English) communication skills is a must

#PKSciences

Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!
Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Vaccine Policy: While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to [email protected].
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
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NIBR
Translational Medicine
USA
East Hanover, NJ
Research & Development
Full Time
Regular
No
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337543BR

Principal Scientist - PK Sciences

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